Research Content:
1. The relationship of circadian rhythms and tumor and its mechanism
Circadian clock is closely related to human life and health, and it regulates nearly all functions of the body such as behavior, physiological processes and metabolism in a significant daily rhythm manner.
Recent reports has shown that circadian can affect cell cycle and apoptosis. Our primary data suggests that dysfunction of circadian rhythm might regulate carcinogenesis. Further study will be conducted to systematically dissect this regulation
2. The signal transduction during cardiovascular development
Unveiling the signal transduction regulatory details involved in cardiovascular development and remod-eling will bring us closer to the big picture of heart development and cardiovascular diseases. Based on our previous results, we will focus on the function and mechanism of signal pathways involved in car-diovascular development that regulated by kinases like Akt, MAKP/p38 and phosphotase like PP2A.
3. The molecular mechanism of metabolism and senescence
The organism goes into senescence as soon as the organism develops into adulthood, while metabo-lism is involved in all the time of development and senescence. The study of the molecular regulatory mechanism of metabolism and senescence will shed light on the understanding of the processes of dis-eases and health of our body. Meanwhile, it will also help us to know the process of development from another angle. Based on our previous results, we will focus on the molecular regulatory mechanism of BDNF, PAX6 and PP2AC in metabolism and senescence and its relationship with development.
4. Establishment and study of more animal models of disease.
Principal Investigator:
Prof. Xiang GAO
gaox@nicemice.cn
Major Members:
Qian GAO, qian_gao@nju.edu.cn
Minsheng ZHU, zhums@nicemice.cn
Ying XU, xuying@nicemice.cn
Chaojun LI, licj@nicemice.cn
Zhongzhou YANG, yangzz@nicemice.cn
Qingshun ZHAO, zhaoqs@nicemice.cn
