Research Subject:
Diabetic nephropathy; Rhein; New drug
Principal Investigator:
Prof. Zhihong LIU
Zhihong-liu@hotmail.com
Research Content & Progress:
The efficacy of rhein (class Ⅰ new drug) for treating diabetic nephropathy (DN) has been studied for more than 20 years. Rhein is a new drug with high efficacy and less adverseness. We have received two Chinese patents (ZL97107137.3, ZL 01108271.2)and one American patent (US 6,197,818 B1). By the supporting of 863 high-tech Programs during the 10th Five-Year Plan, the pre-clinical research of rhein has been completed and was approved by SFDA in 2008 (Approval document no.: 2008L03640, 2008L03643).
“The clinical trial on the efficacy of rhein for treating patients with diabetic nephropathy ” (No:2008ZX09101 (050) also supported by high-tech Programs in the 11th Five-Year Plan . Now we have finished the supplement experiments of pharmacology and toxicology. The Phase Ⅰclinical trial is ongoing. We anticipate to complete the clinical trial by the end of 2012 and be awarded with a certificate of the new drug.
