Research Subject:
Targeting anti-tumor drug development
Principal Investigator:
Prof. Zichun HUA
huazc@nju.edu.cn
Research Content & Progress:
This study is to develop TRAIL mutant with tumor-targeting capability and high efficacy. The aim of this study is to enhance the anti-tumor activity of TRAIL, to reduce its dosage of use, to lower the cost of the user and to decrease its potential side-effect.
We have finished the design of TRAIL mutant, its cloning, expression and purification. We have assessed its anti-tumor ability both in vitro and in vivo, its tumor-targeting capability, tissue distribution and its signaling pathway analysis.
