Research Subject:
Metabolic nuclear receptors; Mitochondria; ER stress; PGC-1a; ATF6
Principal Investigator:
Prof. Chenyu ZHANG
cyzhang@nju.edu.cn
Research Content & Progress:
Metabolic nuclear receptors regulate mitochondria function and ER stress, consequently affect cell metabolism and function. However, the precise mechanism is still unknown. The proposal aims to in-vestigate the role of PGC-1a in liver and vessel smooth muscle cells, and the role of ATF6 in ER stress by using engineered animal models and molecular biologic, chemistry biologic and systems biologic techniques. This study helps us to further understand biologic functions of metabolic nuclear receptors on mitochondria metabolism, ER stress and cell metabolism, and regulatory network of cell metabolism.
