Research Subject:
Bionic Molecular Recognition for early diagnosis of cancer
Principal Investigator:
Prof. Huangxian JU
hxju@nju.edu.cn
Research Content & Progress:
This project will aim at the fundamental study on bionic molecular recognition systems such as aptamers, molecular imprinting materials and biofunctional nanoprobes and so on for biomedical application in early diagnosis and warming of important diseases related to human health (especially for malignant tumor). By combining the frontier research achievements in material science, biomedicine, nanoscience, optoelectronics and analytical chemistry, the research works mainly contain 1) revealing the relationship between function and the structure of bionic molecular recognition system and their weak interaction and evolving rules, and establishing the simulation systems for bionic molecular recognition systems; 2) aiming at the biomarkers at different levels to design, synthesize, select the bionic molecular recognition systems and study their function; 3) developing the highly sensitive and specific imaging and sensing methods based on the bionic molecular recognition systems for the biomarkers related to tumors and tumor cells; 4) searching novel specific tumor biomarkers and exploring the new tools for early warming of tumors; 5) establishing the early diagnosis methods of cancer and the data base of aptamers relating to tumor types, and developing new systems with knowledge property right for the diagnosis of cancer.
