Prof. Zijian GUO
Time:2015-09-10 03:56 Source:未知 Author:chenxiaoqing  Click: 2033

 

His research work focuses on the following aspects: 

1) design of anticancer metal complexes with novel structural features and reactivities. Transitional metals such as platinum, 

palladium, nickel, copper and zinc are employed in these studies; 

2) conjugation of platinum drugs with selective targeting moieties or encapsulation of platinum drugs in host molecules or 

particles to achieve enhanced permeability and retention effect in tumour tissues. For example, bis-phosphonates, peptides, 

proteins and nanoparticles are commonly used in targeting and delivery studies; 

3) Development of a variety of fluorescent sensors which can be used for the detection of biologically essential metal ions, 

environmentally toxic heavy metals, inorganic drug species, DNA nucleases, and small signaling inorganic molecules.